Guan Que was born in 1990 in Tongren County, Huangnan Tibetan Autonomous Prefecture, Qinghai Province. Influenced by his father from a young age, he was immersed in Tibetan culture. Starting from 2007, he formally studied Thangka painting skills under his father, Sangye Pen. He accompanied his father to monasteries in Tibet and Qinghai multiple times to learn about mural painting. Since 2013, he has been involved in the creation of a 56-meter-long Thangka titled "The Chinese Nation as One Family.".

In 2018, I accompanied my father to the National Museum of China to participate in the China Arts and Crafts Biennial.

In November 2018, I went to Beijing to participate in the cultural and creative class organized by the Intangible Cultural Heritage Department of the Ministry of Culture.

The 2019 artwork "Shakyamuni's Eighteen Arhats" was selected as a title-challenging work for the Guinness World Records.

In 2020, he was named as the representative inheritor of Regong art (Thangka), a national-level intangible cultural heritage project.

In 2022, the artwork "Padmasambhava" won the Gold Award at the Hong Kong International Cultural and Art Expo.

The proceeds from the auction of the father-son Tangka artwork "Zodiac Signs • Birthday Buddha" at the 2023 Beautiful China - Rural Volunteer Teaching Project Dinner will be donated to the charity project in the amount of several hundred yuan.

In 2024, I was invited to Hong Kong to participate in the inaugural World Guanyin Culture and Art Festival, where I exhibited my calligraphy and painting works alongside renowned artists and young artists from Hong Kong and Macao.

In 2025, the artwork "Eleven-faced Thousand-armed Avalokitesvara" was successfully selected for the China National Arts and Crafts Biennial and was interviewed by CCTV.

His works have been collected by collectors in mainland China, Hong Kong, and Macao. He is an official artist collaborating with the Vertu brand and a new generation of Thangka artist.